The significantly upregulated top nine DEPs—EFEMP1, CYP3A7, LOXL1, EFEMP2, MFI2, CHST4, CCL21, NPNT, LTBP4 and ANGPTL6, and downregulated top five DEPs—MIF2, ACE, SLC9B2, GRAMD4 and ACACB in the peritumoral microenvironment of HCC are shown in Fig. 3f and g. The gene discussed is EFEMP2; the disease is hepatocellular carcinoma.