UCP1 and acute kidney injury: For example, Quercetin was found to abate AKI through suppressing ferroptosis [14]; Uncoupling protein 1 reduces AKI through inhibiting mitochondrial reactive oxygen species generation [15]; Inhibition of pannexin-1 attenuates sepsis-induced AKI by reducing cell apoptosis and NLRP3 inflammasome activation [16, 17]; and aquaporin 1 blocks AKI through PI3K-mediated macrophage M2 polarization [18].