Furthermore, Fechtner et al. found that CB2 activation significantly inhibits IL-1-induced IL-6 and IL-8 production in human rheumatoid arthritis synovial fibroblasts (Fechtner et al. 2019) and our study results suggest that the production of TNF-α, IL-1β, and IL-6 is significantly inhibited by CB2 activation in NPCs. The gene discussed is CNR2; the disease is rheumatoid arthritis.