In both LL/2 and LL/2-tdTomato/Luc tumor models, neither anti-PD-1 nor anti-CTLA-4 mAb reduced the tumor size although mice challenged with LL/2-tdTomato/Luc cells had significantly smaller tumors compared to mice challenged with LL/2 cells (Fig 5B). This evidence concerns the gene CTLA4 and neoplasm.