In previous work, Hartman et al. 2014 showed in malignant melanoma that S100B binds RSK in a calcium-dependent manner, sterically blocks ERK-dependent phosphorylation of RSK at Thr573, and sequesters RSK to the cytoplasm, and that RSK is re-localized to the nucleus following S100B depletion [8, 33]. This evidence concerns the gene S100B and melanoma.