To further characterize the function of S100B in melanoma, quantitative real-time PCR arrays were used in S100B-targeting (shS100B) or non-targeting scrambled shRNA-expressing (shSCR) WM115 melanoma cells (shSCR and shS100B WM115 hereafter) [8], to identify genes that were either up- or down-regulated upon silencing of S100B expression. The gene discussed is S100B; the disease is melanoma.