A study indicated that levels of E-cadherin decreased before normoalbuminuria concluding that E-cadherin is an early kidney biomarker, a finding that confirms the results of another study which measured urinary soluble E-cadherin and its expression and they demonstrated that the levels significantly raised in the early stage of DN and elevated with the progression of DN [41, 42]. Here, CDH1 is linked to liver dysplastic nodule.