Furthermore, blockade of WNT signaling by a monoclonal antibody to LDL-receptor-related protein 6 (LRP6) ameliorated DN [54] whereas another study found that liraglutide suppressed the production of extracellular matrix proteins and ameliorated renal injury of DN by enhancing Wnt/β-catenin signaling [55]. Here, LRP6 is linked to liver dysplastic nodule.