VEGFA and Blindness: Endophthalmitis (EO) is a severe form of eye inflammation that may result in irreversible blindness if the intraocular infection is not properly treated.3 To our knowledge, the largest meta-analysis on EO to date revealed an overall rate of 0.06% (197 of 350 535 injections) following IVIs with all anti-VEGF agents.4 Anti-VEGF injections require repeated injections on a regular basis.5 Despite that subsequent injections did not increase the risk of EO compared with the first one, awareness of the risk remains clinically relevant as the number of injections increases.4