One difference between the disease models studied here is that in rTg4510 mice, aggregated tau is localized exclusively in the cytoplasm, including prominent pathology in the cell body, whereas both HD models display abundant mHTT IBs in the nucleus, but not in the cell body (Figs 3A and Fig EV3A, and Fig 4A; Davies et al, 1997; Santacruz et al, 2005; Yamamoto et al, 2000). This evidence concerns the gene MAPT and Huntington disease.