Further overexpression of miR-675 and SESN3 was introduced in LC cells pre-treated with si-EGR1, after which the inhibitory functions of si-EGR1 on LC cell growth were blocked after miR-675 overexpression, while overexpression of SESN3 reduced the growth and metastasis of LC cells again. Here, EGR1 is linked to laryngotracheoesophageal cleft.