PRRT2 and Alzheimer disease: For example, an impaired function of PKC was reported in human postmortem AD brains (Cole et al., 1988; Wang et al., 1994), and recent evidence suggests that inhibition of certain PCK isoforms (PKCδ) might help to reduce the progression of the disease in APPswe/PS1dE9 mice (Du et al., 2018).