LGR5 and cancer: Wnt/β‐catenin target gene activity was high across all TC clusters, but stem/TA‐cell‐like cancer cells showed stronger expression of a LGR5‐ISC stem cell signature that is Wnt‐driven (Merlos‐Suárez et al, 2011; Muñoz et al, 2012), but this association was not significant across the patients.