We assigned the SCN‐aberrant primary cancer cell transcriptomes to 40 bins along a gradient of diminishing LGR5‐ISC gene signature activity or along decreasing MAPK activity, and determined expression levels of the stem cell markers LGR5 and EPHB2 (Merlos‐Suárez et al, 2011; Fig 4A). Here, LGR5 is linked to cancer.