EGFR and colorectal carcinoma: For instance, chemoresistance has been linked to subpopulations of CRC cells expressing the transcription factor ZEB2 (Francescangeli et al, 2020), and anti‐EGFR therapy resistance has been associated with rise of stem cell‐like populations (Lupo et al, 2020) and stromal remodeling (Woolston et al, 2019).