Likewise, lineage tracing in CRC cancer models has revealed preferential outgrowth of cancer cell subpopulations defined by expression of genes such as LGR5 or IL17RB (Shimokawa et al, 2017; Goto et al, 2019) or by localization at the leading edge of the tumor (Lamprecht et al, 2017). Here, LGR5 is linked to neoplasm.