ssociations were essentially not modified by further adjustment for current depressive episode, antidepressant use, history of CVD, hypertension, B vitamins (PLP, riboflavin) and low-grade inflammation (composite score of CRP, SAA, sICAM-1, IL-6, IL-8 and TNF-α) (ESM Tables 4 and 5). This evidence concerns the gene IL6 and hypertensive disorder.