CNP and ischemia: Ischaemia-vehicle was associated with a reduction in CNPase positive myelin in the periventricular and parasagittal white matter tracts [1-Factor ANOVA; F(1) = 7.297, P = 0.016, and 2-Factor ANOVA; F(1) = 12.854, P = 0.003, Fig. 2] compared to sham-ischaemia animals, which was not improved with hypothermia or rEpo treatment.