SMAD2 and Brachycephaly: 2016), were particularly effective at defininggenetic variants associated with body size and by extension, “allometric” brachycephaly.Genes in proximity to polymorphisms with the most phenotypic explanatory power includeinsulin-like growth factor 1 (IGF1), insulin-like growth factor 1receptor (IGF1R), high-mobility group AT-hook 2 (HMGA2),stanniocalcin 2 (STC2), growth hormone receptor (GHR),and SMAD family member 2 (SMAD2) and ligand-dependent nuclear receptorcorepressor like (LCORL).