TGFBR1 and head and neck squamous cell carcinoma: To study the dynamic change of active enhancers during HNSCC transformation, we utilized a common-used HNSCC mouse model, a transgenic mouse with a combined Tgfbr1/Pten knockout (K14-CreERtam+/−; Tgfbr1flox/flox; Ptenflox/flox).