MAPK6 and cancer: Among the target genes, Fhl2 was reported to contribute to tongue squamous cell carcinoma and other cancers (Nakazawa et al., 2016; Wang et al., 2016; Li et al., 2021); Mapk6 is a Ser/Thr protein kinase and is related with oral squamous cell carcinoma and other cancers (Rai et al., 2004).