Interestingly, many histone-modifying enzymes involved in enhancer regulation are frequently mutated in cancer cells, such as lysine methyltransferase 2C/D (KMT2C/D, also known as MLL3/4) and E1A binding protein p300/CREB binding protein (p300/CBP), which are key enzymes for H3K4me1 and H3K27ac, respectively (Yao et al., 2020). The gene discussed is CREBBP; the disease is cancer.