Klf7 is an oncogenic TF related with lung adenocarcinoma and gastric cancer (Jiang et al., 2017; Niu et al., 2020); E2f8 is a TF-regulating cell cycle and involved in cervical cancer and hepatocellular carcinoma (Eoh et al., 2020; Kim et al., 2020); Vav1 is associated with esophageal squamous cell carcinoma and indicates poor prognosis, and it is involved in the JNK/SAPK cascade (Möller et al., 2001; Zhu et al., 2017). The gene discussed is MAPK8; the disease is esophageal squamous cell carcinoma.