The values of TB, INR, alanine aminotransferase (ALT), aspartate aminotransferase (AST), MELD, MELD and sodium (MELD-Na), and integrated MELD (IMELD) were significantly higher in the HBV-associated HE group than in the alcohol-associated HE group (p < 0.05), suggesting worse clinical conditions with HBV-associated HE. This evidence concerns the gene GPT and hereditary elliptocytosis.