SNCA and Parkinson disease: Disease modeling efforts have uncovered that midbrain DA neurons generated from PD patients-derived hiPSCs exhibit mitochondrial dysfunction and α-synuclein aggregation as major cellular disease phenotypes (Devi et al., 2008; Byers et al., 2011; Cooper et al., 2012; Imaizumi et al., 2012; Ryan et al., 2013; Flierl et al., 2014; Shaltouki et al., 2015; Chung et al., 2016; Kouroupi et al., 2017).