TNC and neoplasm: As for OC, Cho et al. (2015) demonstrated that the ECM dysregulation (including collagen fibril thickening with perpendicular orientation, hyaluronan accumulation, ECM protein cross-linking, loss of decorin, and upregulation of fibronectin, tenascin-X, and tenascin-C) is attributed to tumor stiffness, which leads to local invasion, distant migration, and tumor progression.