Considering the importance of β-catenin signaling in the development of cancer and EMT process (Ghahhari and Babashah, 2015; Krishnamurthy and Kurzrock, 2018), we were inspired to explore whether ELK3 could regulate the Wnt/β-catenin signaling pathway in pancreatic cancer. This evidence concerns the gene ELK3 and pancreatic neoplasm.