ZEB1 and carcinoma: As one of the most important EMT-inducing transcription factors, ZEB1 not only transcriptionally represses but also activates some EMT-related genes, and its overexpression promotes tumorigenesis and metastasis in human carcinomas (Wellner et al., 2009; Sanchez-Tillo et al., 2011; Krebs et al., 2017).