CRNDE and hepatocellular carcinoma: As a new member of lncRNA family, CRNDE (colorectal neoplasia differentially expressed) is initially identified as the specifically upregulated lncRNA in human colorectal cancer, and afterward confirmed to be highly expressed in many other malignancies including HCC (Ellis et al., 2012; Wang et al., 2015; Xie et al., 2018).