Recent studies have shown that CRNDE affects the expression and/or activity of some miRNAs as a sponge (Chen et al., 2016; Wang et al., 2018; Ji et al., 2019), while several miRNAs have impact on the stability of ATG4B mRNA in various cancer cells (Liao et al., 2016; Wu et al., 2016; Liu Y. et al., 2019). The gene discussed is ATG4B; the disease is cancer.