In contrast, representative HF-related WNT signaling genes WNT5A (DP marker) and LEF1 (DP > HF-epithelial marker) were downregulated in KC-DP constructs compared to DPCs by 1.9-fold (p = 0.095) and 25-fold (p < 0.01), respectively (Figure 2B). This evidence concerns the gene LEF1 and hydrops fetalis.