Folliculogenic EMIs can partially be induced in vitro by the spheroid culture of HF-related epithelial and dermal cell mixtures (e.g., KCs and DP cells), which would not allow full recapitulation of three-dimensional (intercompartmental and directional) features of EMIs (Havlickova et al., 2009; Yen et al., 2010). This evidence concerns the gene TBCE and hydrops fetalis.