Mannose conjugated PSs (Zhang et al., 2017) to target mannose receptors that may be overexpressed in breast cancer cells, EGF conjugated PSs for targeting EGFR receptors (Kuo et al., 2010), cannabinoid CB2 receptor (a G-protein coupled receptor)/translocator protein (a mitochondria membrane receptor) targeted PSs (Yang et al., 2017; Zhang J. et al., 2018) can also be utilized for active targeting strategies in breast cancer (Savellano et al., 2005; Eccles, 2011; Shirasu et al., 2013). Here, EGF is linked to breast cancer.