Since EIF4A3 is involved in various RNA metabolic processes, including nonsense-mediated RNA decay and RNA splicing, for example, EIF4A3-induced circular RNA ASAP1 (circASAP1) facilitates tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1/2 signaling pathway (40). The gene discussed is MAP2K1; the disease is glioblastoma.