MAPK10 and hepatocellular carcinoma: Concomitantly, the expression of ICAM1 in MAPK10-deficient Huh7-shMAPK10 cell line was significantly lower than in the control Huh7-pLKO cell line, suggesting that the silencing of MAPK10 leads to reduced expression of ICAM1 in HCC tumor cell context (P = 0.0401; Figure 6D).