Importantly, we found that expression of top thirty hub genes predicted by Cytohubba was positively and significantly correlated with the expression of MAPK10 in HCC patients (Pearson correlation coefficient R2 ≥ 0.20, P < 0.0001; Table 3), suggesting that they were expressed in a MAPK10-associated manner. The gene discussed is MAPK10; the disease is hepatocellular carcinoma.