We uncovered that the decrease of MAPK10 expression in HCC patients was positively correlated with the reduction of stromal cell gene expression signatures (correlation coefficient R = 0.59. P = 1.6 × 10−36; Figure 2A), suggesting that the expression of MAPK10 in the development and progression of HCC might be associated with the differential abundance of cancer-associated fibroblasts (CAFs) or other stromal cells (24–26). Here, MAPK10 is linked to hepatocellular carcinoma.