Furthermore, interaction between ICAM1 and LFA-1 is known to activate hereby identified hub genes (ZAP70 and LCK) in T cells (37), suggesting that ICAM1 could act as a core mediator of the proposed capacity of MAPK10 to regulate hub genes in the immunocytes in the TME of HCC patents. This evidence concerns the gene MAPK10 and hepatocellular carcinoma.