ITGAL and liver cancer: This result indicated that ICAM1 might bridge the MAPK10-instigated intercellular signal transduction and the crosstalk between liver cancer and stromal cells and the immunocytes, preventing the evasion of immune surveillance by cancer cells, consistent with previous reports showing that the intracellular interaction between ICAM1 and LFA-1 promotes LFA-1-mediated costimulation in T cells and T cell motility, as well as activation and general adhesion of the leukocytes (9, 35–37).