ICAM1 and hepatocellular carcinoma: Because ICAM1, which plays the key role in the immune cell recruitment and signaling (38, 39), was highlighted by several of our analyses as the potential MAPK10 target gene, we explored the correlation between MAPK10 and ICAM1 expression in HCC patients and found that the expression of MAPK10 was positively correlated with the expression of ICAM1 (R2 = 0.26, P = 2.91 × 10−9; Figure 6B).