Another group of HCC patients (Cluster 3 in Supplementary Figure 1C, n = 81) who had high transcriptional scores of distinct immune cells, high expression of major histocompatibility complex class I/II (MHC-I/II), high expression of the genes involved in the IFN response, inflammation and cytolytic activity were defined as HCC patients with high immune activity. Here, IFNA1 is linked to hepatocellular carcinoma.