EIF4E and neoplasm: Activation of mTORC1 causes phosphorylation of 4E-BPs (on T37, T46 and S65 of 4E-BP1), leading to dissociation of 4E-BPs from eIF4E to allow eIF4F assembly and augment cap-dependent translation of a subset of cellular mRNAs important for tumorigenesis and maintenance of tumor growth (4, 5).