mTORC1 signaling in leukemia cells regulates other growth and survival factors besides cyclin D3 and MCL-1; for example, knockdown or inhibition of mTORC1 in human T-ALL cells reduces expression of the oncoprotein c-MYC while increasing expression of the pro-apoptotic protein PUMA (8). Here, CCND3 is linked to acute lymphoblastic leukemia.