αKlotho is produced by the kidneys, is considered to be an early biomarker for CKD, and may have extra autonomous anticalciuric and phosphaturic action, independent of FGF-23 [22]. In CKD, assembly of both membrane-bound and αKlotho leads to an increase in the serum levels of FGF-23 due to decreased FGF-23 clearance, leading to phosphate retention. This evidence concerns the gene FGF23 and chronic kidney disease.