The five most significantly regulated DEGs in PAH-HPASMC were ISLR, SCD, DHCR24, PAPPA2 and DMKN. The top five most up-regulated genes were found to be XIST, PSG4, ADGRF5, CDH5 and PECAM1. The gene discussed is DHCR24; the disease is pulmonary arterial hypertension.