Yokoyama et al. previously reported that a single-nucleotide polymorphism (SNP) in IPMK, which is associated with decreased expression of IPMK, was detected in samples from tissues of Alzheimer’s disease and immune-mediated diseases including RA, suggesting that IPMK is a risk factor for chronic inflammatory diseases (Yokoyama et al. 2016). Here, IPMK is linked to early-onset autosomal dominant Alzheimer disease.