The previous research of the research group confirmed that the phosphorylation expression of ERK5 pathway protein, the main subfamily of mitogen-activated protein kinase (MAPK) signaling pathway, is closely and negatively correlated with the progression of CHF [4], and Wenyang Zhenshuai Granules can significantly upregulate the expression of ERK5 protein phosphorylation. Here, MAPK7 is linked to congestive heart failure.