To further investigate the effects of the PI3K/Akt/mTOR pathway on HGF-induced meningioma cells, we treated IOMM-Lee cells with a c-MET inhibitor (SU11274, 5 μmol/l) and a PI3K inhibitor (LY29400225, μmol/l), respectively, and then the proliferation, migration, invasion, and EMT were detected. The gene discussed is HGF; the disease is meningioma.