Studies have found that BRIP1 can promote the invasion of breast cancer (BC) cells by regulating the expression of multiple downstream target genes, such as MGAT5, EPCAM, and CXCL12, especially in the triple-negative phenotype MDA-MB-231 cell line (Rizeq et al., 2020). The gene discussed is CXCL12; the disease is breast carcinoma.