IL4 and colon carcinoma: Similar to satellite cells, MABs accumulated in cachectic muscles and when they are isolated from the atrophic muscles are still able to directly contribute to myogenesis in vivo. In C26 colon carcinoma-bearing mice the function of muscle stem cells can be preserved by the administration of interleukin 4 (IL-4) that acts as anabolic agent to skeletal muscle, reducing also systemic inflammation and increasing muscle protein synthesis (Costamagna et al., 2020).