However, SNAI3–AS1 has been reported to promote the proliferation and metastasis of HCC cells (Li et al., 2019, 2020); DGCR9 can enhance the proliferation, migration, and glucose uptake of gastric cancer cells (Ni et al., 2018); DICER1–AS1 promotes malignant behavior of osteosarcoma, colorectal cancer, and other tumors (Gu et al., 2018; Afrough et al., 2020; Ma et al., 2020); and LncRNA C1RL-AS1 silencing inhibited the malignant phenotype of gastric cancer cells through the Akt/β-catenin/c-myc pathway (Zhen-Hua et al., 2020). This evidence concerns the gene C1RL and osteosarcoma.