LMX1B and open-angle glaucoma: In conclusion, our study did not observe any direct association between allele and genotype frequencies of SNPs rs35934224 and rs6478746 in TXNDR2 and LMX1B, respectively, and POAG or its related phenotypes such as IOP and cup/disc ratio, suggesting that these SNPs may not be significant risk factors of POAG in this ethnic group.