Although recent studies demonstrated an association of SNPs rs35934224 and rs6478746 in TXNDR2 and LMX1B, respectively, in POAG patients of European origin (Bailey et al., 2016; Gharahkhani et al., 2018), our study did not find a similar pathogenic association of these SNPs in POAG patients of Saudi origin. Here, LMX1B is linked to open-angle glaucoma.