With several polymorphisms reported to be associated with POAG or related endophenotypic traits (Abu-Amero et al., 2015), we investigated whether SNPs rs35934224 (TXNRD2) and rs6478746 (LMX1B) are associated with POAG in the middle-eastern cohort of Saudi Arabia and report a negative association of these variants with POAG in this ethnic group. The gene discussed is LMX1B; the disease is open-angle glaucoma.