MYC and cancer: Some notable examples are: the role of RAS and PI3K pathways in prostate and breast cancers and their therapeutic responses (Yue et al., 2002; Haagenson and Wu, 2010), the Wnt signaling pathway in colorectal and other cancers (Zhan et al., 2017), the Hippo pathway in melanoma (Zhang X. et al., 2020), and the MYC pathway in prostate cancer progression and treatment response (Arriaga et al., 2020).