ACE2 and Autoimmunity: While the aetiology of Long-COVID remains undetermined, speculation is currently focused on two possibilities including, (1) that SARS-CoV-2 infections might promote autoimmunity; an association seen for Epstein Barr Virus and Chikungunya virus (Bastard et al., 2020; Cañas, 2020); and (2) that that the utilisation of ACE2 by SARS-CoV-2 as a cellular entry mechanism might down-regulate ACE2 expression and disrupt its essential roles in cellular and tissue homoeostasis (Ashraf et al., 2021).