With the exception of N. gonorrhoeae, the activation of ASMase in different pathogens, such as E. coli, Staphylococcus aureus, Listeria monocytogenes, Salmonella typhimurium, and Mycobacterium avium, is essential for bacterial infection (Esen et al., 2001; Utermohlen et al., 2003; Falcone et al., 2004; McCollister et al., 2007; Utermohlen et al., 2008). Here, SMPD1 is linked to bacterial infectious disease.