However, what appears to differentiate the pathological outcomes, of the neurodegenerative diseases, are the presence of disease-specific “endogenous factors,”' which trigger the inflammatory processes: amyloid-beta for AD, α-synuclein for PD, mutant SOD1 for ALS, and myelin-peptide-mimetic for MS (38). The gene discussed is SNCA; the disease is neurodegenerative disease.