The PI3K/AKT/mTOR signaling cascade is a major signaling pathway involved in cell proliferation and protein synthesis in a variety of cell types including cancer cells and PASMCs (Goncharov et al., 2014; Sahoo et al., 2016; Meng et al., 2017; Babicheva et al., 2021). The gene discussed is MTOR; the disease is cancer.