It is well established that serum insulin levels correlate with SU (Quinones Galvan et al., 1995; Gill et al., 2013; MacFarlane et al., 2015; Wang et al., 2017) and insulin in euglycemic hyperinsulinemia, induced by euglycemic clamp protocols, reduces renal fractional excretion of urate (Quinones Galvan et al., 1995; Muscelli et al., 1996; Ter Maaten et al., 1997). This evidence concerns the gene INS and hyperinsulinism.