Indeed, physiological euglycemic hyperinsulinemia induced by insulin infusion (6 pmol/min/kg) in healthy volunteers acutely reduces urinary urate (25–35%) (Quinones Galvan et al., 1995; Muscelli et al., 1996; Ter Maaten et al., 1997), suggesting a key role for insulin in the pathogenesis of hyperuricemia. This evidence concerns the gene INS and hyperinsulinism.