LMNA and familial dilated cardiomyopathy: Indeed, Lmna H222P mutation results in an abnormal increase of sarcolipin, an inhibitor of the sarco/endoplasmic reticulum (SR) Ca2+ ATPase (SERCA) in mouse ventricular CMs, leading to altered calcium handling already in the early stage of DCM, before changes in left ventricular function have occurred (Morales Rodriguez et al., 2020).