Sayed et al. (2020) showed that LMNA K117fs mutation causes epigenetic silencing of Krüppel-like factor 2 (KLF2) in hiPSCs–derived ECs, which in turn leads to impaired KLF2-mediated EC response to shear stress and EC dysfunction. Impaired shear stress response has also been noted in endothelium-specific progeria mouse model (Osmanagic-Myers et al., 2018). Here, KLF2 is linked to progeroid syndrome.