Further, age-dependent biochemical remodeling of the ryanodine receptor 2 (RYR2) in the heart that lead to “leaky” RYRs and a subsequent increase of the SR Ca2+ leak has been shown to play a role in cardiomyopathy caused by LMNA H222P mutation (Dridi et al., 2021). Here, RYR2 is linked to cardiomyopathy.