Since patients carrying the myopathic form of CPTII deficiency display normal fat turnover at rest (Orngreen et al., 2002) and physical exercise was recognized as the most common trigger factor involved in myalgia and/or rhabdomyolytic events, current recommendations exclude the practice of all types of physical activities, in particular prolonged and strenuous exercise, and complete rest is still recommended (Joshi and Zierz, 2020). The gene discussed is CPT2; the disease is Myalgia.