These data are particularly relevant considering that PGC-1α stimulates not only the mitochondrial function but also the peroxisomal biogenesis/activity (Bagattin et al., 2010; Huang et al., 2017), and this effect may positively affect the mitochondria-peroxisome biochemical interplay, a potential alternative pathway to sustaining the energy requirements of exercise in CPTII deficiency patients. This evidence concerns the gene CPT2 and hyperinsulinemic hypoglycemia, familial, 4.