Recently, we employed a different and more specific approach to generate a mutant mouse model with proximal tubule-specific deletion of NHE3, PT-Nhe3−/−, to test our hypothesis on the important roles of NHE3 in the proximal tubules in basal blood pressure control and Ang II-induced hypertension (Li et al., 2018, 2019a). Here, AGT is linked to hypertensive disorder.