Furthermore, deletion of AT1a receptors in the proximal tubules attenuated ~50% of Ang II-induced hypertension in PT-Agtr1a−/− mice, compared with wild-type mice, but completely blocked intracellular Ang II fusion protein-induced hypertension in PT-Agtr1a−/− mice (Li et al., 2021). This evidence concerns the gene AGTR1 and hypertensive disorder.