However, we and others have shown that infusion of Ang II for weeks continues to induce progressive hypertension and target organ kidney injury (von Thun et al., 1994; Zou et al., 1996; Zhuo et al., 2002; Li et al., 2007; Li and Zhuo, 2008b, 2011, 2013), suggesting that this classical paradigm should be revised to include the intracellular system (Kurtz and Gardner, 1998; De Mello and Danser, 2000; Re, 2000; Kumar et al., 2008). The gene discussed is AGT; the disease is Hypertension.