Indeed, an impaired pressure natriuresis response has been reported in SHR (Roman and Cowley, 1985; Roman, 1987) and animal models of L-NAME- (Majid et al., 1993; Granger and Alexander, 2000), 2-Kidney, 1-Clip (Rostand et al., 1982), TGR (mRen-2)27- (Gross et al., 1994; Zhuo et al., 1999), and Ang II-induced hypertension (Mattson et al., 1991; Wang et al., 2000; Zhuo et al., 2002; Li et al., 2011a, 2021). Here, AGT is linked to Hypertension.