The reasons for this discrepancy are not clear but several reports have now confirmed AKT, and by implication PI3K to which it often coupled, as a downstream player in ErbB receptor-dependent vascular dysfunction in models of diabetes (Benter et al., 2015; Kasan et al., 2015b; Amin et al., 2011). The gene discussed is AKT1; the disease is diabetes mellitus.