Additionally, there is also evidence in the non-diabetic vasculature that acute EGFR signaling may mediate the contractions of GPCR ligands such as Ang II and endothelin (ET-1) (Kawanabe et al., 2004; Lucchesi et al., 2004) that also play an important role in mediating diabetes-induced vascular dysfunction. This evidence concerns the gene AGT and diabetes mellitus.