Hyperglycemia associated with diabetes is known to lead to the generation of reactive oxygen species (ROS) such as via NADPH oxidase (NOX) activity (see also The Link Between Epidermal Growth Factor Receptor & Nicotinamide Adenine Dinucleotide Phosphate Oxidase in Diabetes-Induced Vascular Dysfunction) that can lead to cardiovascular complications (Brownlee, 2005; Zhang et al., 2020; Babel and Dandekar, 2021). The gene discussed is FMO5; the disease is diabetes mellitus.