Interestingly a very recent study showed that increased EGFR signalling in the rat brain, namely within the hypothalamic paraventricular nucleus (PVN), may also play a key role in mediating myocardial-infarction-induced heart failure through enhancing ERK1/2-induced sympathetic overactivity (Yu et al., 2021). This evidence concerns the gene EGFR and myocardial infarction.