Furthermore, high glucose- or diabetes-induced ErbB3, and Erbb4 transactivation could be ameliorated by Ang-(1–7) treatment thereby suggesting that Ang-(1–7) acts as a pan-inhibitor of the EGFR/ErbB/HER family of receptor tyrosine kinases (Akhtar et al., 2015). This evidence concerns the gene EGFR and diabetes mellitus.