Administration of gefitinib also prevented depletion of SERCA2a (sarcoplasmic endoplasmic reticulum Ca2+ ATPase2a) and NCX1 (sodium-calcium exchanger-1) in streptozotocin-induced cardiomyopathy-indicative of improved Ca2+ homeostasis during myocardial contractility (Shah et al., 2018). This evidence concerns the gene SLC8A1 and cardiomyopathy.