In animal models of diabetes, Ang-1-7 can attenuate NADPH oxidase and NF-kB activity and prevent vascular dysfunction without markedly correcting hyperglycemia (Benter et al., 2007; Benter et al., 2008; Al-Maghrebi et al., 2009; Yousif et al., 2014). This evidence concerns the gene NFKB1 and Hyperglycemia.