Src family of non-receptor tyrosine kinases appear to be key upstream effectors of EGFR/ErbB RTKs as hyperglycemia/diabetes is known to induce EGFR/ErbB signaling via a Src-dependent mechanism (Akhtar et al., 2012a; Akhtar et al., 2015; see also The Interplay of Epidermal Growth Factor Receptor and Angiotensin 1-7, a Member of the Renin-Angiotensin-Aldosterone System, in Diabetes-Induced Vascular Dysfunction below). The gene discussed is REN; the disease is diabetes mellitus.