AGT and diabetes mellitus: Although the precise mechanistic details through which Ang-(1–7) exerts its beneficial actions are not yet fully elucidated, it appears that Ang-(1–7) prevents diabetes-induced vascular dysfunction, at least in part, via inhibiting Ang II-mediated transactivation of EGFR/ErbB family of receptor tyrosine kinases (Akhtar et al., 2012a; Akhtar et al., 2015).