EGFR and diabetes mellitus: This initial research on vascular EGFR was conducted in a preclinical model of type 1 diabetes (streptozotocin-induced diabetes in rats) and its findings were subsequently replicated in the vasculature of animal models of type 2 diabetes (Belmadani et al., 2008; Palen and Matrougui, 2008; Choi et al., 2012; Galan et al., 2012; Kassan et al., 2015a; Stern et al., 2020), implying that dysregulated EGFR/ErbB1/HER1 signaling was a common mediator of vascular complications in both Type 1 and Type 2 diabetes.