Stimulation of EGFR/ErbB receptors by amphiregulin (AR), another member of EGF family of ligands, induced cardiac fibrosis after myocardial infarction (Liu et al., 2018; Liu et al., 2020) highlighting the detrimental role of EGFR/ErbBs in cardiac pathology. The gene discussed is EGF; the disease is myocardial infarction.