In contrast, there is now a growing body of evidence that supports the notion that chronic or persistent overexpression/activation of EGFR/ErbB family of receptors can play a detrimental role (see Table 2) in the pathological heart including in cardiac hypertrophy, fibrosis and cardiac remodeling associated with diabetes (e.g., Kobayashi and Eguchi, 2012). Here, EGFR is linked to cardiac hypertrophy.