NOS3 and Hyperglycemia: For example, (-)-Epigallocatechin-3-gallate (EGCG), a highly effective component in green tea that has anti-inflammatory as well as antioxidant and free radical scavenging properties, was able to inhibit eNOS uncoupling and prevent hyperglycemia-induced endothelial dysfunction and apoptosis by activating the PI3K/AKT/eNOS pathway (Zhang and Zhang, 2020).