As EGFR/ErbB/HER receptors are known drivers of cell growth and proliferation via mitogenic signaling through Ras/Raf/MAP kinases, AKT and ERK1/2, they play key role in mediating cardiac hypertrophy (Peng et al., 2016; Bi et al., 2020). The gene discussed is EGFR; the disease is cardiac hypertrophy.