EGFR and diabetes mellitus: The first in vivo reports demonstrating a direct link between EGFR signaling and diabetes-induced vascular dysfunction appeared in 2005 which showed that enhanced EGFR/ErbB1 signaling was a key mediator of diabetes-induced vascular dysfunction as pharmacological inhibition of this RTK was corrective of this pathology in the mesenteric vascular bed as well as in renal and carotid arteries (Benter et al., 2005a; Benter et al., 2005b; Yousif et al., 2005).