In contrast, there is now a growing body of evidence that supports the notion that chronic or persistent overexpression/activation of EGFR/ErbB family of receptors can play a detrimental role (see Table 2) in the pathological heart including in cardiac hypertrophy, fibrosis and cardiac remodeling associated with diabetes (e.g., Kobayashi and Eguchi, 2012). The gene discussed is EGFR; the disease is diabetes mellitus.