EGFR and hypertensive disorder: For example, EGF via stimulation of EGFR elicited potent vasoconstriction in aortic strips from a rat model of hypertension (Florian and Watts, 1999); and EGFR activation via MMP-2 reportedly increased ROS formation and facilitated contraction in non-diabetic aortas (Prado et al., 2018).