EGFR and diabetes mellitus: Since it is now known that GPCRs can initiate transactivation of the EGFR (e.g., Akhtar et al., 2015; Forrester et al., 2016), which is expressed in both endothelial cells and VSMCs (e.g., Akhtar et al., 2012a; Schreier et al., 2021), there is strong indications that EGFR signalling may also be a key player in mediating vascular pathology in diabetes (Akhtar and Benter, 2013; Matrougui, 2010; Schreier et al., 2014; Schreier et al., 2018).