Generally, the typical pathological characteristics of AD occur many years before the onset of clinical symptoms with the progressive accumulation of extracellular amyloid β (Aβ) plaques outside neurons and hyperphosphorylated tau (p-tau)-composed neurofibrillary tangles (NFTs) inside neurons, accompanied by neuronal death, synapses loss and global brain atrophy (Spires-Jones and Hyman, 2014; Zhang T. et al., 2021). Here, MAPT is linked to Brain atrophy.