Several publications have reported that APOE ε4 affects sleep in cognitively healthy individuals (Drogos et al., 2016; Kahya et al., 2017) and that it might also play a modulatory effect between sleep and AD pathology (Lim et al., 2013; Burke et al., 2016; Hwang et al., 2018). This evidence concerns the gene APOE and Alzheimer disease.