In addition, C1q upregulation (Dandoy-Dron et al., 1998, 2000; Carroll et al., 2018), C3 upregulation and colocalization with neurons, and MAC deposition on neurons were observed in infected human brain (Kovacs et al., 2004) as well as in scrapie model in mice (Lv et al., 2014), suggesting the activation of the classical and terminal pathways. The gene discussed is C3; the disease is scrapie.