EIF2AK3 and transient ischemic attack: Recently, researchers found that Hes1 knockdown aggravated the neural apoptosis through the PERK pathway where the level of p-eIF2α enhanced dramatically in transient cerebral ischemia model because the increase of infarct size and a deterioration of the nervous system are counteracted with PERK-specific inhibitors GSK2606414 (Li Y. et al., 2020).