In the investigation of the neuroprotective mechanism of granulocyte colony stimulating factor (G-CSF)on ischemic stroke, it was found that the expression of ATF4, CHOP, caspase-12 related to the apoptosis pathway induced by ER stress decreased, and the mice showed signs of better ER homeostasis reconstruction and less acute neuronal degeneration of post-ischemic stroke (Modi et al., 2020). The gene discussed is ATF4; the disease is ischemic stroke.