Inflammatory signaling pathways in cerebral ischemia include toll-like receptors (TLR) signaling pathway, MAPK signaling pathway, and NF-κB signaling pathway, the latter two are mainly driven by UPR under ER stress (Marsh et al., 2009; Lanzillotta et al., 2013; Mo Y. et al., 2020). Here, NFKB1 is linked to Cerebral ischemia.