Furthermore, a 2011 study by Pabon et al. (2011) found that in the 6-hydroxydopamine (6-OHDA) rat model of PD, striatal delivery of exogenous recombinant FKN proved to be neuroprotective by reducing the size of the dopaminergic lesion, as well as reduced neuronal loss. The gene discussed is CX3CL1; the disease is Parkinson disease.