In multiple models of PD, increasing the concentration of soluble FKN has proven to be neuroprotective by inhibiting microglial activation, downregulating pro-inflammatory cytokine production, and protecting DA neurons from degeneration (Cardona et al., 2006; Pabon et al., 2011; Morganti et al., 2012). The gene discussed is CX3CL1; the disease is Parkinson disease.