The data showed that the SHOX2 and RASSF1A methylation panel in bronchoalveolar lavage fluid (BALF) yielded a diagnostic sensitivity of 81.0% and specificity of 97.4% with an AUC value of 0.892 in lung cancer diagnosis, but it was showed a lower sensitivity in adenocarcinoma of 69.6%34. This evidence concerns the gene SHOX2 and lung cancer.